Feasibility of A Network Meta-Analysis in Endometriosis.

Gonadotropin-releasing hormone agonists (GnRH agonists) are widely recognised as an effective treatment for patients with moderate to severe symptomatic endometriosis. In addition, the role of GnRH antagonists is being explored. GnRH analogues act by modifying the release of follicle-stimulating hormone (FSH) and luteinising hormone (LH), thereby suppressing ovarian estradiol production. GnRH agonists are effective in reducing endometriosis-associated pain but are associated with estrogendeprivation-related side effects such as hot flushes, loss of libido and loss of bone mass.1 As new treatments are developed it will be important to understand how their efficacy and safety compare to those treatments already widely prescribed.